Endocrine Abstracts

Introduction: Growth retardation in sickle cell children is common and multifactorial. Recent evidence suggests damage to the somatotropic axis. We report the case of a patient followed for homozygous sickle cell anemia and in whom we discover an associated GH deficiency.Observation: It is a 13 year old child followed for homozygous sickle cell anemia, splenectomized for 2 years, not polytransfused. We were sent to the hematology department before a dela...

Introduction: Papillary Thyroid Carcinoma (PTC) is the most frequent cancer of the thyroid. PTC may rarely coexist with Primary hyperparathyroidism (PHPT). Furthermore, the association of PTC and graves’ disease (GD) has been described and the existence of a link between these entities has long been investigated, but no clear correlation has been established. We report the case of a female patient who suffered from GD, PTC and PHPT.Observation: A 34...

Introduction: The majority of systemic diseases result from an autoimmune process. Primary adrenal insufficiency (Addisson’s disease AD) is also frequently caused by an autoimmune process. Their association is rare but can be seen in the framework of autoimmune polyendocrinopathies. We report 2 observations associating an autoimmune adrenal insufficiency with a systemic disease.Observation 1: We describe the case of a 50-year-old patient initially a...

Introduction: Gilbert syndrome is a common autosomal dominant hereditary condition characterized by intermittent unconjugated hyperbilirubinemia in the absence of hepatocellular disease or hemolysis. Multiple endocrine neoplasia (MEN) is defined by the association of a neoplasia or hyperplasia of at least two endocrine glands and caused by multiple mutations. Rare cases of atypical MEN were reported in the literature. We report the case of a patient with a history of gilbert&#...

Introduction: Prolactinomas are the most common of functional pituitary tumors. Dopamine agonists are the first line treatment of prolactinomas but have antagonistic effect with antipsychotics (dopamine receptor blockers) used in schizophrenia. The association between these two illnesses is a medical challenge, as the treatment of one disease can exacerbate the symptoms of the other one.Clinical case: We report the case of a 72-year old man, newly diagno...

Introduction: The use of GH treatment in patients with macroadenomas and GH deficiency is of concern to the clinician due to the theoretical stimulation of tumor regrowth by GH substitution. We report the case of an 18-year-old adolescent with a macroprolactinoma causing delayed stature and puberty.Observation : We report the case of an 18-year-oldadolescent who consulted for gynecomastia with delayed stature and puberty. Physical examination displayed a...

Introduction: Turner’s syndrome (TS) affects 1/2500 female births and it is characterized by growth retardation, dysmorphic syndrome and gonadal dysgenesis. Our objective was to describe the clinical, therapeutic and evolutive features of Tunisian patients with TS.Patients and Methods: It was a retrospective study including 23 patients with TS diagnosed between 1993 and 2019.We noted clinical, therapeutic and evolutive data for each patient.<p ...

Introduction Growth hormone (GH ) deficiency is a rare but not exceptional cause of statural delay in children. The results of GH stimulation tests and the exploration of other pituitary axes allow us to conclude on the nature of the deficiency: total or partial and its possible association with other pituitary deficits.MethodsThis is a retrospective descriptive study including 75 patients followed for congen...

IntroductionGrowth hormone deficiency (GHD) is a rare cause of statural retardation in children. The diagnosis is evoked in front of a bundle of anamnestic, clinical and radiological arguments. Treatment consists of substitution by recombinant GH with the aim of restoring normal size. There is interindividual variability in the response to treatment. We therefore proposed to study the response to treatment as well as the predictive factors of this respon...

IntroductionCongenital GH deficiency is more common in boys than in girls. Several differences have been noted between the 2 genders. We proposed to study these differences for epidemiological, auxological and anthropometric characteristics.MethodsThis is a retrospective study including 75 patients followed for congenital GH deficiency in the endocrinology department at the National Institute of Nutrition in ...